In the early years of the American occupation a group of intrepid and pioneering families from Surigao, Leyte and Bohol settled along the rich agricultural lands bordering Hinaguimitan River. They came in bancas, which they used as their principal means of transportation from Surigao and by which means they also carried downstream to the town of Surigao their products consisting mainly of abaca, rice, root cops and bananas.

Sometime in 1916, the road that is now the national highway was constructed linking Surigao, to which the barrio of Sison then belonged, to the outlying southern municipalities of the province. At about that time, the inhabitants of the then barrio of Sison transferred the site of the barrio along the national road that is its present site. A certain Lt. Daniel Sison of the Philippine Constabulary was among the prominent public functionaries of the province at that time and it was in his honor, perhaps in recognition of his commendable services in the maintenance of peace and order, that the then barrio of Sison was named after him.

On February 1, 1960, the barrio of Sison became a separate municipality by virtue of an Executive Order of Pres. Carlos P. Garcia.

Source: 1970 Souvenir Program of Philippine Public Schools Inter-scholastic Athletic Association Meet (PPSIAA)